David Pearce in interview on the The Anatomy of Happiness.
While researching epilepsy, neuroscientist Itzhak Fried stumbled on a ‘mirth’ center in the brain – given this, what ought we be doing to combat extreme suffering and promote wellbeing?
0:00 Mastery of reward circuitry
0:25 Itzhak Fried’s experiments on stimulating ‘the Humor Centre’ of the brain
2:25 What should Effective Altruists be doing about the biological roots of suffering?
3:00 The consequences of taking the Ipsos poll on reported happiness at face value
4:24 Tackling biological and genetic causes of suffering & malaise
5:37 Cost effectiveness for long-term impacts of pre-implantation genetic screening
6:40 Effect of low mood on quality of life & economy
7:36 Genes & alleles associated with low or high hedonic set points: ADA2b deletion variant, COMT gene, serotonin transporter gene, FAAH & FAAH OUT gene, SCN9A gene
8:19 CRISPR and the future of modifying the genetic source code
8:45 Slow progress in psychopharmacology and issues of opioid dose escalation
9:41 Genetic predispositions to super-happy & super-healthy
Is the worry one might be locked in such an affective psychosis just the product of idle scepticism? Given the cognitive inaccessibility of most of the generically ecstatic states alluded to here, perhaps one wouldn't know if one were so afflicted. After all, damaged and disfigured minds may have limited self-insight. Nor would one necessarily have the conceptual resources even to grasp what was at stake if one suffered from such a neural deficit. Pure, "unearned", genetically-driven bliss of even the mildest flavour detracted from the inclusive fitness of one's genes in the ancestral environment. Constitutionally happy freaks-of-nature got eaten or outbred. Hence unipolar euphoric mania today is vanishingly rare; unipolar melancholic depression and chronic dysthymia are all too common. Is one's potential unease, if not revulsion, at the prospect of paradise-on-earth an incidental cultural by-product of natural selection? Or has selection pressure ensured that one is genetically predisposed to be biased against the idea of enduring bliss in the first instance?
Read more at The Hedonistic Imperative.
And relatedly David Pearce brought to our attention that ‘The Telegraph’ reports that the comedy brain cell has been discovered.
Is humour just some primitive defence mechanism of Darwinian life, soon to go the way of the dodo? I normally assume so. But soon we’ll have the technology to make everything seem superhumanly funny.