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Longevity Day with Aubrey de Grey!

“Longevity Day” (based on the UN International Day of Older Persons – October 1) is a day of support for biomedical aging and longevity research. This has been a worldwide international campaign successfully adopted by many longevity activists groups. In this interview Aubrey de Grey lends support to Longevity Day and covers a variety of points, including:
– Updates: on progress at SENS (achievements, and predictions based on current support), funding campaigns, the recent Rejuvenation Biotechnology conference, and exciting news in health and medicine as it applies to longevity
– Advocacy: What advocates for longevity research need to know
– Effective Altruism and Science Philanthropy – giving with impact – cause prioritization and uncertainty – how to go about measuring estimates on impacts of dollars or units of effort given to research organizations
– Action: High impact areas, including more obvious steps to take, and some perhaps less obvious/underpopulated areas
– Leveraging Longevity Day: What to do in preparation to leverage Longevity Day? Once one has celebrated Longevity Day, what to do next?

“Longevity Day” (based on the UN International Day of Older Persons – October 1st) is a day of support for biomedical aging and longevity research. This has been a worldwide international campaign successfully adopted by many longevity activists groups.

Here is the Longevity Day Facebook Page.

longevity-advocacy-action-aubrey-de-grey-longevity-day-oct-1st

Longevity Day Melbourne 2016

“Longevity Day” (based on the UN International Day of Older Persons – October 1st) is a day of support for biomedical aging and longevity research. This has been a worldwide international campaign successfully adopted by many longevity activists groups.
Venue: Level 1, 20 Queen Street, Melbourne, Australia 3000

Agenda:
3.00pm Guests Dr. Randal A. Koene and Keith Wiley – who’ll take part in a live conversation about the metaphysics of mind-uploading.
4.00pm Representative of Stasis Systems Australia, Matt Fischer – who’ll be talking about the current state of cryonics in Australia, it’s desirability and then a Q&A session afterwards.
5.00pm Co-ordinator Adam Karlovsky – who’ll be directing an inclusive discussion about the ethics, promises and pitfalls of life extension.

Afternoon snacks and drinks will be provided, and you are encouraged to bring some to share, or for yourself if you have any dietary requirements.

A social dinner may be organized afterwards, somewhere close by. Express interest if you’d enjoy coming along.
Because centrally located venues are hard to come by for small groups, there’s a small $5 entry to cover electricity and cleaning.

This is Melbourne’s first Longevity Day celebration ever, so bring along your friends and family to help make this a good one!

Alongside Longevity Day is the conference for the International Society on Aging and Disease (ISOAD) that will take place in Stanford, on September 30 – October 2

Here is a Video for Longevity Day with Aubrey de Grey put on by SciFuture titled ‘Longevity, Advocacy & Action’:

longevity-day-melbourne

Here is the Longevity Day Facebook Page.

Strategies for Engineered Negligible Senescence with Aubrey de Grey

Projects at SENS Foundation

aubrey-de-grey-stragegies-for-engineered-negligable-senescenceSens Foundation has a lot of projects that were working on all at the same time.  There are 3 projects that we are working on at our research center in California and then there are a whole bunch of others that we support at university laboratories around the world – mostly in the USA.
In the research center in Mountain View California there are 3 projects that we are working on:

  1. 1st of all, mitochondrial mutation – we’re interested in combating the accumulation of mitochondrial mutations, not actually via repairing them, but by making them harmless; by putting modified copies of the mitochondrial genes into the nuclear dna, modified in such a way that the proteins go back to the right place – even though the dna is in the wrong place. This is an idea that was actually pioneered in Australia by a group in Monash University – about 25 or 27 years ago even.  But has actually been very challenging to make work in general.  Over the last few years a number of breakthroughs have been made to make the whole thing much more realistic, and we’re perusing that with a lot of energy now.
  2. The 2nd thing we’re working on at the research center is to identify enzymes from the environment (especially from bacteria) that can break down substances whose accumulation in the body over life causes diseases like cardiovascular disease and macular degeneration. We’ve become quite good at finding enzymes that break down these substances, and now were developing ways to put them into mammalian cells in manners that actually allow the cells to survive longer.  We’ve just published in the April of 2012 the first demonstration of rescue of cells from toxic substances that accumulate in the body using a system of this nature.
  3. The 3rd thing we are doing at the research center is part of our cancer project – we’re interested in combating cancer by controlling the elongation of ends of chromosomes – these things called ‘telomeres‘ and were working specifically on a rather neglected area in that field called ALT (Alternative Lengthening of Telomeres) which is a method that about 10% of cancers use that is still very characterized genetically and we’re working on that.

Video interview here:

Medical Bioremediation

The elimination of this junk which accumulates inside cells using enzymes from bacteria is what we call medical bioremediation. We call it that because bioremediation is the use of very much the same method to eliminate pollutants from the environment as a method of environmental decontamination.
Bioremediation works extremely well; it’s not just an academic idea; it’s a thriving commercial discipline. And it certainly shows us that it’s pretty straight forward to find enzymes to break down more-or-less whateever you want so long as the thing you want to break down is organic, and rich in energy – so that the microbe can break it down and it can live off it.

The Divide & Conquer Approach to Solving Aging

Most of the work going on that is related to SENS is not directly related to longevity. And that’s because the SENS approach to combating aging is a ‘divide and conquer’ approach; an approach in which we split the problem of aging into a number of sub-problems and we address each of those individually.
In any divide an conquer approach to a complex technological problem you don’t expect to see any actual results in terms of the overall goal of the technology until all of the components are at least working reasonably well. And we’re certainly not at that stage yet. So yes, there’s masses of progress at SENS in various of the strands that we’ve been perusing – but that has not yet translated into a longevity benefit yet in any species. However there is plenty of work going on in simpler strategies to combat aging; strategies that we don’t pursue because they won’t scale – they will only give you a modest benefit postponing the diseases and disabilities of old age.
But which we’re very much happy for other people to pursue in because they may be easier to implement in human beings than the SENS approach. So, for example a few years ago it was discovered that the drug named Rapamycin was able to significantly extend the life-span of rodents – which is quite a surprise because the drug had been around a long time. But you know there have been a lot of studies of how that happens ever since that time – and we may be able to turn that into a useful therapy for human beings.
There is still a lot of excitement around drugs that emulate calorie restriction that extends lifespan of rodents especially, by tricking them (essentially) into thinking they are in a famine when they’re not. And of course there’s a lot of work going on still in trying to evaluate other approaches to combating aging by simple methods – there is always constantly new news in this area.

Will Any of the SENS Approaches Work in Isolation?

More videos about SENS can be browsed through in this playlist:

Strategies for Engineered Negligible Senescence (SENS) is the term coined by British biogerontologist Aubrey de Grey for the diverse range of regenerative medical therapies, either planned or currently in development,[1] for the periodical repair of all age-related damage to human tissue with the ultimate purpose of maintaining a state of negligible senescence in the patient, thereby postponing age-associated disease for as long as the therapies are reapplied.[2]

The term “negligible senescence” was first used in the early 1990s by professor Caleb Finch to describe organisms such as lobsters and hydras, which do not show symptoms of aging. The term “engineered negligible senescence” first appeared in print in Aubrey de Grey’s 1999 book The Mitochondrial Free Radical Theory of Aging,[3] and was later prefaced with the term “strategies” in the article Time to Talk SENS: Critiquing the Immutability of Human Aging[4] De Grey called SENS a “goal-directed rather than curiosity-driven”[5] approach to the science of aging, and “an effort to expand regenerative medicine into the territory of aging”.[6] To this end, SENS identifies seven categories of aging “damage” and a specific regenerative medical proposal for treating each.

[1]Research Themes (February 4, 2013) http://www.sens.org/research/introduction-to-sens-research

[2] de Grey, Aubrey; Rae, Michael (September 2007). Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime. New York, NY: St. Martin’s Press, 416 pp. https://www.amazon.com/Ending-Aging-Rejuvenation-Breakthroughs-Lifetime/dp/0312367074

[3] de Grey, Aubrey (November 2003). The Mitochondrial Free Radical Theory of Aging. Austin, Texas: Landes Bioscience. ISBN 1-58706-155-4. http://www.sens.org/files/pdf/MiFRA-06.pdf

[4] de Grey AD, Ames BN, Andersen JK, Bartke A, Campisi J, Heward CB, McCarter RJ, Stock G (April 2002). “Time to Talk SENS: Critiquing the Immutability of Human Aging”. Annals of the New York Academy of Sciences 959: 452–62. http://www.sens.org/files/pdf/manu12.pdf

[5] Bulkes, Nyssa (March 6, 2006). “Anti-aging research breakthroughs may add up to 25 years to life”. The Northern Star. Northern Illinois University (DeKalb, USA). http://northernstar.info/city/anti-aging-research-breakthroughs-may-add-up-to-years-to/article_a4d2acd9-475d-5e12-a81c-77011f9c65ad.html http://www.worldhealth.net/news/anti-aging_research_breakthroughs_may_ad/

[6] “Age-Related Diseases: Medicine’s Final Adversary?”. Huffington Post Healthy Living. http://www.huffingtonpost.com/aubrey-de-grey-phd/age-related-diseases_b_985019.html

Longevity & the Future of Fun with Jamais Cascio

I asked Jamais Cascio about The Hedonistic Imperative & longevity as part of my interview with him, and got some interesting responses

Cascio warns about wireheading* – Jamais urges cautious about changing cognitive systems to increase pleasure because we may lack a sufficient understanding of the 2nd or 3rd order effects – which isn’t to say that we should never ever do it.  Though he is usually not someone to jump at a chance to apply the precautionary principle, he thinks this is one case that warrants it.

 

Longevity may increase peoples tendency to be thoughtful about the future – imagine a decade to think about the ramifications of a certain action (or inaction).

If we have more ability to think about the consequences of our actions, we have a greater ability not just to see the future, but to see ourselves in the future.

Since we evolved to think about our immediate relations, we are somewhat selfish – living a long time might cause us to be more concerned about the future and those in it.

I believe that one of the benefits of radical life-extension will be the radical expansion of our sense of time – our presence in time.

Jamais Cascio on Life Extension & the Hedonistic Imperative.00_01_02_11.Still008

*Note, it should be clear that Wireheading isn’t the same as re-calibration of the hedonic treadmil that David Pearce advocates. See this interview with David Pearce on the subject of wireheading for more details.

Source: Wonder Workshop

Source: Wonder Workshop

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Superlongevity – Mini Documentary

Short documentary on longevity science going mainstream and surrounding public opinion – with some key folk in the transhumanist movement discussing the issues around aging and the state of play, how to think rationally about aging and longevity medicine, media performance, common objections to longevity technology, advocacy, how the public may come to terms with and ultimately accept longevity technology.

I hope to be developing this documentary further in the near future.

Starring : Aubrey de Grey, Max More, Michael Shermer, George Dvorsky, David Pearce and Ramez Naam.

Ramez NaamRamez Naam is a professional technologist and science fiction writer. He was involved in the development of widely used software products such as Microsoft Internet Explorer and Microsoft Outlook. His last role at Microsoft was as a Partner Group Program Manager in Search Relevance for Live Search.  Naam currently holds a seat on the advisory board of the Acceleration Studies Foundation, is a member of the World Future Society, a Senior Associate of the Foresight Institute, and a fellow of the Institute for Ethics and Emerging Technologies.

MAx1Max More is a philosopher and futurist who writes, speaks, and consults on advanced decision-making about emerging technologies.  Founder of the Extropy Institute, Max More has written many articles espousing the philosophy of transhumanism and the transhumanist philosophy of Extropianism, most importantly his Principles of Extropy.  At the start of 2011, Max More became president and CEO of the Alcor Life Extension Foundation, an organization he joined in 1986.

Michael-Shermer1-500x500_cMichael Brant Shermer is a science writer, historian of science, founder of The Skeptics Society, and Editor in Chief of its magazine Skeptic, which is largely devoted to investigating pseudoscientific and supernatural claims. The Skeptics Society currently has over 55,000 members. Shermer also engages in debates on topics pertaining to pseudoscience and religion in which he emphasizes scientific skepticism.

David Pearce - Healesville SanctuaryDavid Pearce is a British philosopher who promotes the idea that there exists a strong ethical imperative for humans to work towards the abolition of suffering in all sentient life. His book-length internet manifesto The Hedonistic Imperative outlines how technologies such as genetic engineering, nanotechnology, pharmacology, and neurosurgery could potentially converge to eliminate all forms of unpleasant experience among human and non-human animals, replacing suffering with gradients of well-being, a project he refers to as “paradise engineering”.

aubreyeagleAubrey de Grey is an English author and biomedical gerontologist, currently the Chief Science Officer of the SENS Research Foundation. He is editor-in-chief of the academic journal Rejuvenation Research, author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). He is known for his view that medical technology may enable human beings alive today to live indefinitely

George Dvorsky San FranGeorge Dvorsky is a Canadian bioethicist, transhumanist, and futurist. He is a contributing editor at io9 and producer of the Sentient Developments blog and podcast. Dvorsky currently serves as Chair of the Board for the Institute for Ethics and Emerging Technologies (IEET) and is the founder and chair of the IEET’s Rights of Non-Human Persons Program, a group that is working to secure human-equivalent rights and protections for highly sapient animals.

 


 

All footage footage is either my own, is news under ‘fair use’ (in line with the 4 factors of fair use) or I have permission from the owners.

Stay tuned, as there will be further updates.

Current version: v1.0 (video)

Previous versions:
v0.91 (video)
v0.9 (video)

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