Extending Life is Not Enough

Dr Randal Koene covers the motivation for human technological augmentation and reasons to go beyond biological life extension.

randal_koene_squareCompetition is an inescapable occurrence in the animate and even in the inanimate universe. To give our minds the flexibility to transfer and to operate in different substrates bestows upon our species the most important competitive advantage.” I am a neuroscientist and neuroengineer who is currently the Science Director at Foundation 2045, and the Lead Scientist at Kernel, and I head the organization, which is the outreach and roadmapping organization for the development of substrate-independent minds (SIM) and also previously participated in the ambitious and fascinating efforts of the nanotechnology startup Halcyon Molecular in Silicon Valley.

Slides of talk online here
Video of Talk:

Points discussed in the talk:
1. Biological Life-Extension is Not Enough Randal A. Koene
3. No one wants to live longer just to live longer. Motivation informs Method.
4. Having an Objective, a Goal, requires that you have some notion of success.
5. Creating (intelligent) machines that have the capabilities we do not — is not as good as being able to experience them ourselves… Imagine… creating/playing music. Imagine… being the kayak.Imagine… perceiving the background radiation of the universe.
6. Is being out of the loop really your goal?
7. Near-term goals: Extended lives without expanded minds are in conflict with creative development.
8. Social
9. Gene survival is extremely dependent on an environment — it is unlikely to survive many changes.Worse… gene replication does not sustain that which we care most about!
10. Is CTGGAGTAC better than GTTGACTGAC? We are vessels for that game — but for the last10,000 years something has been happening!
11. Certain future experiences are desirable, others are not — these are your perspectives, the memes you champion…Death keeps stealing our champions, our experts.
12. Too early to do uploading? – No! The big perspective is relevant now. We don’t like myopic thinking in our politicians, lets not be myopic about world issues ourselves.
14. Life-extension in biology may increase the fragility of our species & civilization… More people? – Resources. Less births? – Fewer novel perspectives. Expansion? – Environmental limitation.
15. Biological life-extension within the same evolutionary niche = further specialization to the same performance “over-training” in conflict with generalization
16. Aubrey de Grey: Ultimately, desires “uploading”
18. Significant biological life-extension is incredibly difficult and beset by threats. Reality vs. popular perception.
19. Life-extension and Substrate-Independence are two different objectives
20. Developing out of a “catchment area” (S. Gildert) may demand iterations of exploration — and exploration involves risk.Hard-wired delusions and drives. What would an AGI do? Which types of AGI would exist in the long run?
21. “Uploading” is just one step of many — but a necessary step — for a truly advanced species
22. Thank You

There is a short promo-interview for the Singularity Summit AU 2012 conference that Adam Ford did with Dr. Koene, though unfortunately the connection was a bit unreliable, which is noticeable in the video:

Most of those videos are available through the SciFuture YouTube channel:


Wireheading with David Pearce

Is the Hedonistic Imperative equivalent to wire-heading?
People are often concerned about the future being a cyber-puink dystopia where people are hard wired into pleasure centers like smacked out like lotus eating milk-sops devoid of meaningful existence. Does David Pearce’s Hedonistic Imperative entail a future where we are all in thrall to permanent experiential orgasms – intravenously hotwired into our pleasure centers via some kind of soma like drug turning us into blissful-idiots?

Adam Ford: I think some people often conflate or distill the Hedonistic Imperative to mean ‘wireheading’ – what do you (think)?

David Pearce: Yes, I mean, clearly if one does argue that were going to phase out the biology of suffering and live out lives of perpetual bliss then it’s very natural to assimilate this to something like ‘wireheading’ – but for all sorts of reasons I don’t think wireheading (i.e. intercrainial self-stimulation of the reward centers and it’s pharmacological equivalent) is a plausible scenario for our future. Not least there will presumably always be selection pressure against wireheading – wireheads do not want to have baby wireheads and raise wirehead children.
I think a much more credible scenario is the idea that were going to re-calibrate the hedonic treadmill and allow ourselves and our future children to enjoy lives based on gradients of intelligent bliss. And one of the advantages of re-calibration rather than straight forward hedonic maximization is that by urging recalibration one isn’t telling people they ought to be giving up their existing preferences or values is that if your hedonic set-point (i.e. your average state of wellbeing) is much higher than it is now your quality wireheads - white of life will really be much higher – but it doesn’t involve any sacrifice of the values you hold most dear.
As a rather simplistic way of putting it – clearly where one lies basically on the hedonic axis will impose serious cognitive biases (i.e. someone who is let’s say depressive or prone to low mood) at least will have a very different set of biases from someone who is naturally cheerful. But none-the-less it doesn’t entail, so long as we aim for a motivational architecture of gradients of bliss, it doesn’t entail giving up anything you want to hold onto. I think that’s really important because a lot of people will be worried that somehow that if, yes, we do enter into some kind of secular paradise – it will involve giving up their normal relationships, their ordinary values and what they hold most dear. Re-calibration does not entail this (wireheading).

Adam Ford: That’s interesting – people think that you know as soon as you turn on the Hedonistic Imperative you are destined for a very narrow set of values – that could be just one peek experience being replayed over and over again – in some narrow local maximum.

wirehead-utility-function-hijacking1024x448David Pearce: Yes – I suppose one thinks of (kind of) crazed wirehead rats – in fairness, if one does imagine orgasmic bliss most people don’t complain that their orgasms are too long (and I’m not convinced that there is something desperately wrong with orgasmic bliss that lasts weeks, months, years or even centuries) but one needs to examine the wider sociological picture – and ask ‘is it really sustainable for us to become blissed out as distinct form blissful’.

Adam Ford: Right – and by blissed out you mean something like the lotus eaters found in Odysseus?

David Pearce: Yes, I mean clearly it is one version of paradise and bliss – they call it meditative tranquility (not doing anything) – but there are other versions of bliss in which one is hyper-motivated. It seems that, crudely speaking, motivation (which is mediated by the meso-limbic dopamene system) and raw bliss (which is associated with mu-opiod activation of our twin hedonic-hotspots) – the axis are orthogonal. Now they’re very closely interrelated (thanks to natural selection) – but in principle we can amplify one or damp down the other. Empirically, at any rate it seems to be the case today that the happiest people are also the most motivated – they have the greatest desires – I mean, this runs counter to the old buddhist notion that desire is suffering – but if you actually look at people who are depressive or chronically depressed quite frequently they have an absence of desire or motivation. But the point is we should be free to choose – yes it is potentially hugely liberatery – this control over our reward architecture, our pleasure circuitry that biotechnology offers – but let’s get things right. We don’t want to mess things up and produce the equivalent of large numbers of people on Heroin – and this is why I so strenuously urge the case for re-calibration – in the long run genetically, in the short run by various no-recreational drugs.

Clearly it is one version of paradise and bliss – they call it meditative tranquility (not doing anything) – but there are other versions of bliss in which one is hyper-motivated.David Pearce

Adam Ford: Ok… People may be worried that re-calibrating someone is akin to disrupting the continuum of self (or this enduring metaphysical ego) – so the person at the other end wouldn’t be really a continuation of the person at the beginning. What do you think? How would you respond to that sort of criticism?

wireheading - static David PearceDavid Pearce: It depends how strict ones conception of what personal identity is. Now, would you be worried if to learn tomorrow that you had won the national lottery (for example)? It would transform your lifestyle, your circle of friends – would this trigger the anxiety that the person who was living the existence of a multi-millionaire wasn’t really you? Well perhaps you should perhaps you should be worried about this – but on the whole most people would be relatively relaxed at the prospect. I would see this more as akin to a small child growing up – yes in one sense as one becomes a mature adult one has killed the toddler or lost the essence of what it was to be a toddler – but only in a very benign sense. And by aiming for re-calibration and hedonic enrichment rather than maximization, there is much less of a risk of loosing anything that you think is really valuable or important.

Adam Ford: Okay – well that’s interesting – we’ll talk about value. In order to not loose forms of value – even if you don’t use it (the values) much – you might have some values that you leave up in the attic to gather dust – like toys that you don’t play with anymore – but you might want to pick up once in a thousand years or what not. How do you then preserve complexity of value while also achieving high hedonic states – do you think they can go hand in hand? Or do you think preserving complexity of value reduces the likelihood that you will be able to achieve optimal hedonic states?

David Pearce: As an empirical matter – and I stress empirical here – it seems to be the case that the happiest are responsive to the broadest possible range of rewarding stimuli – it tends to be depressives who get stuck in a rut. So other things being equal – by re-calibrating ourselves, becoming happy and then superhappy – we can potentially at any rate, yes, enrich the complexity of our lives with a range of rewarding stimuli – it makes getting stuck in a rut less likely both for the individual and for civilization as a whole.
I think one of the reasons we are afraid of some kind of loss of complexity is that the idea of heaven – including in traditional christian heaven – it can sound a bit monotonous, and for happy people at least one of the experiences they find most unpleasant is boredom. But essentially it should be a matter of choice – yes, someone who is very happy to, let’s say, listen to a piece of music or contemplate or art, should be free to do so, and not forced into leading a very complex or complicated life – but equally folk who want to do a diverse range of things – well that’s feasible too.

For all sorts of reasons I don’t think wireheading… is a plausible scenario for our future. Not least there will presumably always be selection pressure against wireheading – wireheads do not want to have baby wireheads and raise wirehead children.David Pearce

– video/audio interview continues on past 10:00

Curing Aging – Bill Andrews on Staying Healthy Indefinitely

Bill discusses the groundbreaking science of ‘telomere biology’ – Bill sees this as the first and only emergent technology that holds the promise of treating and reversing age-related diseases, including aging itself.

Curing Aging - Bill Andrews - Book Cover_The Book ‘Curing Aging’ can be found on Amazon

“Topics discussed include the biological basis for the human aging process, the basic science behind telomeres and telomerase, a history of Dr. Andrews’ discoveries at Sierra Sciences, the most exciting experiments demonstrating the promise of therapies based on telomere length maintenance, and the diseases that could be treated or cured by this technology. Dr. Andrews is the President and CEO of Sierra Sciences, a biotech company focused solely on reversing aging through telomere maintenance. He is one of the principal discoverers of both the RNA and protein components of human telomerase, the enzyme most critical to this technology. He has focused the last 20 years of his career exclusively on addressing the problem of human aging. All profits from the sale of this book go to anti-aging research.”

Curing Aging - Bill Andrews on Staying Healhty Indifinitely - portrait


Dr. Andrews has worked in the biotech industry for 28 years, focusing the last 15 years on finding ways to extend human lifespan through the intervention of telomere shortening in human cells.
Dr. Andrews earned his Ph.D. in Molecular and Population Genetics at the University of Georgia in 1981. He was a Senior Scientist at Armos Corporation and Codon Corporation, Director of Molecular Biology at Codon and at Geron Corporation, and Director of Technology Development at EOS Biosciences.
While Director of Molecular Biology at Geron Corporation from 1992 to 1997, Dr. Andrews was one of the principal discoverers of both the RNA and protein components of human telomerase and was awarded 2nd place as “National Inventor of the Year” in 1997 for this work. He is presently a named inventor on 35 US issued telomerase patents.
Dr. Andrews is an avid runner and enjoys participating in ultramarathons in his spare time. His ultimate goal is to run a 7 minute mile at the age of 130.

About Sierra Sciences

sierra_sciences_logoSierra Sciences, LLC, a Reno biotech company, is always looking for people experienced in Protein Chemistry, Cellular Biology, Molecular Biology, High-throughput Drug Screening (HTS) and Pharmaceutical Drug Development. We ask that interested people please apply.

Our lab is located in the middle of Northern Nevada’s technology district! With over 10,000 square feet, our lab is a prominent state-of-the-art research center in the area.

Many thanks to Alberto Seveso for the artwork.

Michio Kaku – A History of a Time to Come

Science, Technology & the Future interviews Dr. Michio Kaku on Artificial Intelligence and the Singularity, Biotech and Nanotechnology

  • What is it that is driving this revolution?
  • How do you think your background in Theoretical Physics shape your view on the future of the mind?
  • Intelligence enhancement, Internet of the mind – brain-net, like a hive mind? Where are we at with AI?
  • Many AI experts and scientists agree that some time in the future a Singularity will be possible (often disagreeing about when). What are your thoughts on the Singularity?
  • What about advances in Nanotechnology?
  • Is the Sticky Fingers problem a show stopper?

Michio is the author of many best sellers, most recently “the Future of the Mind” – We are entering a golden age of neuroscience – today it seems much of the discourse today seems to be it’s use in helping understand and treat mental illness (which is great) – though in the future, there will be other profound implications to understanding neuroscience – such as understanding the mechanics of intelligence…


Michio Kaku’s Biography

Michio Kaku (born January 24, 1947) is an American theoretical physicist, the Henry Semat Professor of Theoretical Physics at the City College of New York, a futurist, and a communicator and popularizer of science. He has written several books about physics and related topics, has made frequent appearances on radio, television, and film, and writes extensive online blogs and articles. He has written three New York Times Best Sellers: Physics of the Impossible (2008), Physics of the Future (2011), and The Future of the Mind (2014).

Kaku is the author of various popular science books:
– Beyond Einstein: The Cosmic Quest for the Theory of the Universe (with Jennifer Thompson) (1987)
– Hyperspace: A Scientific Odyssey through Parallel Universes, Time Warps, and the Tenth Dimension (1994)
– Visions: How Science Will Revolutionize the 21st Century[12] (1998)
– Einstein’s Cosmos: How Albert Einstein’s Vision Transformed Our Understanding of Space and Time (2004)
– Parallel Worlds: A Journey through Creation, Higher Dimensions, and the Future of the Cosmos (2004)
– Physics of the Impossible: A Scientific Exploration into the World of Phasers, Force Fields, Teleportation, and Time Travel (2008)
– Physics of the Future: How Science Will Shape Human Destiny and Our Daily Lives by the Year 2100 (2011)
– The Future of the Mind: The Scientific Quest to Understand, Enhance, and Empower the Mind (2014)

Also see this previous interview with Michio Kaku:


The Future of the Mind‘ – Book on Amazon.

Many thanks to Think Inc. who brought Dr Kaku to Australia!

Subscribe to the Science, Technology & the Future YouTube Channel


Science, Technology & the Future

Michio Kaku – The Future of the Mind – Intelligence Enhancement & the Singularity

Scifuture interview with popular scientist Michio Kaku on the Scientific Quest to Understand, Enhance & Empower the Mind!

The audio of this interview is found here.

Dr. Michio Kaku advocates thinking about some of the radical Transhumanist ideas we all know and love – here he speaks on the frontiers of Neuroscience, Intelligence Enhancement, the Singularity, and his new book ‘The Future of the Mind’!

String theory stems from Albert Einstein’s legacy; it combines the theory of general relativity and quantum mechanics by assuming the multiverse of universes. String field theory then uses the mathematics of fields to put it all into perspectives. Dr Kaku’s goal is to unite the four fundamental forces of nature into one ‘unified field theory’, a theory that seeks to summarise all fundamental laws of the universe in one simple equation.

Note Scifuture did another interview with Michio Kaku – the article can be found here, audio can be found here, and the video can be found here.


The Future of the Mind‘ – Book on Amazon.

Many thanks to Think Inc. who brought Dr Kaku to Australia!

Subscribe to the Science, Technology & the Future YouTube Channel


Science, Technology & the Future